|Arbeitgeber||Northwestern University- Feinberg School of Medicine|
|Standort||Chicago, United States|
|Veröffentlicht||26. February 2014|
|Gültig bis||26. April 2014|
A postdoctoral researcher is needed for a neuroscience lab at Northwestern University Feinberg School of Medicine, Dept of Neurology. Our research is focused on elucidating the basic mechanisms of neurodegeneration with emphasis on understanding amyloid formation and the role of cellular degradation pathways such as autophagic and lysosomal systems. We use a variety of techniques ranging from biochemistry, cell biology, and molecular biology, to characterize patient derived neurons generated from induced pluripotent stem cells (iPSC). Our research is concentrated on mechanisms that govern a-synuclein aggregation, and how the amyloid forming process results in neurodegeneration in Parkinson’s disease (PD) and other age-related neurodegenerative disorders.
The successful applicant will be expected to lead an independent research project related to the laboratory’s general field of interest of neurodegeneration, including but not limited to 1) the role of amyloid formation in dysfunction of the secretory pathway, membrane trafficking, and lipid raft integrity 2) the role of amyloid formation in mitochondrial damage and oxidation, 3) the role of autophagy and lysosomes in cellular aging and neurodegenerative disease.
The job presents a unique opportunity to generate and characterize iPSC’s derived from reprogrammed fibroblasts of patients collected within our neurology clinic. The successful applicant will gain experience in basic lysosomal biology, protein aggregation mechanisms, genome editing techniques to correct disease-causing mutations in iPSC lines, and differentiation of iPSC’s into midbrain dopaminergic and cortical-type neurons. The project will focus on phenotype analysis of patient neuronal lines, and establishing novel assays to use for translational purposes. To this end, opportunities may be offered for collaboration with biotech companies on target validation projects that are focused on developing therapies for neurodegenerative disease.
We are a member of the newly formed Center for Rare Neurological Diseases at Feinberg (http://www.feinberg.northwestern.edu/sites/crnd/index.html ). This provides a valuable collaborative environment connecting researchers from various disciplines such as nanotechnology, medicinal chemistry, and neuroproteomics, and allows for an exceptional opportunity to extend/translate our work on neuronal disease modeling into development of novel therapies.
Interested applicants should provide a CV, short description of research interests, and names/contact info of at least three references.